Background
Osteoarthritis
Osteoarthritis is a degenerative joint disease that primarily affects the cartilage, which is the protective tissue that cushions the ends of bones within a joint. It is the most common form of arthritis and typically develops over time due to wear and tear on the joints, although other factors such as genetics, obesity, joint injuries, and aging can contribute to its onset. The main characteristic of osteoarthritis is the gradual breakdown and loss of cartilage in the affected joints. The most commonly affected joints in osteoarthritis include the knees, hips, hands, and spine. Symptoms can vary from mild to severe, and they tend to worsen over time. Some individuals may experience intermittent flare-ups of symptoms, while others may have persistent discomfort.
Osteoarthritis is a prevalent condition in India, affecting a significant number of individuals. India has a high burden of osteoarthritis due to various factors, including an aging population, sedentary lifestyles, increasing obesity rates, and a lack of awareness about preventive measures and early intervention. It is the most frequent joint disease with a prevalence of 22% to 39% in India. The prevalence of osteoarthritis in India varies across different regions and population groups. Studies have shown that knee osteoarthritis is the most common form of the disease in India, followed by hip osteoarthritis and hand osteoarthritis.
Iminosugars
Plants produce sugars by photosynthesis and also produce a wide range of iminosugars to prevent herbivores and pathogens using those sugars efficiently. Iminosugars are a type of sugar where a nitrogen atom has replaced the oxygen atom in the ring of the structure. This small change can disrupt or restore certain cellular functions, giving iminosugars multiple medicinal properties, which include helping the body reduce inflammation. Robert Nash, Ph.D., is a world-renowned researcher in the field of phytochemistry and a pioneer in the study of iminosugars. Dr. Nash and his research teams at Aberystwyth University in the United Kingdom have discovered nearly 200 iminosugars, including many with potential medicinal uses. He has published more than 250 research papers on iminosugars. For his scientific contributions, Dr. Nash was awarded the first Pierre Fabre Phytochemical Society of Europe Award. Among Dr. Nash’s discoveries is ido-BR1, the only iminosugar clinically tested to support joint health. Found in certain varieties of cucumber, ido-BR1 helps the body modulate Tumor Necrosis Factor Alpha and other biological markers associated with joint health. Peer -reviewed clinical research shows that a specific iminosugar, ido-BR1, is more effective than glucosamine-chondroitin for soothing joint discomfort and increasing flexibility and function. The active component remained unknown because it was an iminosugar and difficult to detect by usual analytical methods.
What is Q-actin™?
Q-actin™ is a 100% natural and patented ingredient to support, improve and strengthen joint health. It is an extract sourced from select cucumbers (Cucumis sativus L.) with high levels of ido-BR1 that soothes joint discomfort and increases flexibility and function.
Mechanism of Action
Q-actin™ functions within the body by effectively inhibiting the activity of Tumor Necrosis Factor alpha (TNF-α), a signaling molecule released by immune cells to coordinate immune responses against potential threats or damaged tissues. Both in vivo and ex vivo studies conducted on humans have provided evidence that Q-actin™ can effectively reduce the levels of TNF-α through various mechanisms.